Oncology Quick Quiz
A 67 year old male who presented with a 3 week history of word finding difficulties, right sided neglect and superior quadrantonopsia was found to have a multifocal L temporal and parietal heterogenous and cystic mass lesion that was biopsied demonstrating glioblastoma multiforme. Molecular analyses reveal the tumor to be unmethylated at the promoter region of the O-6-methylguanine-DNA methyltransferase gene, MGMT and overamplification of EGFR. IDH 1 or 2 mutations are not identified. What is the best course of action?