Oncology Quick Quiz

Your patient develops ovarian cancer at age 55, and has comprehensive germline BRCA1 and BRCA2 mutation testing by a reliable clinical laboratory, which is negative. Sometime later her tumor is sequenced and a BRCA2 mutation is found. Your patient is convinced that this results means that the germline sequencing missed her mutation, and wants to get re-testing of her germline. She is concerned about her children inheriting the mutation. You tell her that: