MSI-High Colorectal Cancer: ASCO Tumor Boards

This course is available as part of the 2016 ASCO Tumor Boards bundle.

This is a case-based activity that includes discussion of a 45-year-old man who presents with right lower quadrant abdominal pain. CT imaging showed suspected diverticulitis but no metastatic disease and he was treatment with empiric antibiotics. After completion of antibiotics, he underwent a colonoscopy which revealed a 4-mm tubular adenoma in the transverse colon and a mass in the cecum biopsy which confirms poorly differentiated invasive adenocarcinoma.  

At the end of this course, users should be able to:

  • Discuss the epidemiology, histopathologic characteristics, and diagnosis of microsatellite instability (MSI) and DNA mismatch repair enzyme deficiency (dMMR) in patients with colorectal cancer.
  • Differentiate hereditary and sporadic MSI-high colorectal cancer.
  • Evaluate the prognostic implications of MSI-high status in stage II colon cancer patients and the impact of MSI-high status on efficacy of adjuvant chemotherapy in these patients.
  • Identify and apply novel therapeutic approaches, including immunotherapy, for patients with MSI-high colorectal cancer.

IMPORTANT NOTE: This course expires on April 20, 2019. Participants must complete all necessary course components by this date.