Metastatic Non-Small Cell Lung Cancer in the Older Adult: ASCO Tumor Boards

This course is available as part of the 2016 ASCO Tumor Boards bundle.

This is a case-based activity that presents two cases of 76-year-old men with similar histories of smoking. In the first case, CT imaging revealed a 3-cm endobronchial mass involving the left hilum with bilateral hilar and mediastinal lymphadenopathy and liver lesions concerning for metastases; no brain metastases on MRI brain. EBUS-guided biopsy of one of the involved lymph nodes confirms squamous cell carcinoma of the lung. In the second case, CT Imaging showed 3-cm mass involving the left hilum with bilateral hilar and mediastinal lymphadenopathy and bilateral adrenal lesions concerning for metastases; no brain metastases on MRI brain. EBUS-guided biopsy of one of the involved lymph nodes confirms squamous cell carcinoma of the lung. Case presentation is followed by discussion about the importance of factors outside of age and ECOG performance status that influence clinical outcomes in older adults.

At the end of this course, participants should be able to:

• Identify issues in intensity of cancer treatment and patient heterogeneity among older adults with advanced non-small cell lung cancer (NSCLC)

• Describe the geriatric assessment (GA) tools in evaluating risk for chemotherapy toxicity and related outcomes in older adults with advanced NSCLC

• Apply GA tools to cancer treatment decision-making regarding older adults with advanced NSCLC as illustrated by a clinical vignette