Diffuse Large B-cell Lymphoma (March 2016): Molecular Oncology Tumor Boards

This free case-based activity includes a crowd-sourced discussion of a 55-year-old female who presented with several weeks history of progressive left cervical adenopathy. The patient FNA suggested high grade neoplasm and excisional biopsy was recommended. A left cervical LN excisional biopsy showed a lymphoid malignancy comprised of large cells with moderate amounts of cytoplasm. The neoplastic cells had vesicular chromatin and prominent nucleoli. Mitotic figures were numerous.

Originally posted on a forum in the ASCO Connection, users now have the opportunity to claim CME, completion, or participation certificates for completing this activity. 

Learning Objectives:

  • Recognize molecular subtypes of DLBCL and expected outcomes of these
  • Evaluate currently available molecular work up of patients with newly diagnosed DLBCL and methods of molecular subtype classification 
  • Discuss how molecular subtype of DLBCL drives selection of therapy, including ongoing clinical studies landscape 

Competencies Addressed

Medical Knowledge (ACGME, AAPA)

Health Promotion, Health Protection, Disease Prevention, and Treatment (ONS)