CNS Tumor (IDH1 Mutation): Molecular Oncology Tumor Boards

This free case-based activity includes a crowd-sourced discussion of a 41-year-old woman who developed new onset right focal seizures and aphasia in 2004. MRI revealed a non-enhancing left parietal mass that was followed after seizures were controlled with an anti-epileptic. In 2013, she developed increased seizure frequency and MRI showed slow progression of the non-enhancing left parietal mass and now a faint hint of enhancement could be seen.

Originally posted on a forum in the ASCO Connection, users now have the opportunity to claim CME, completion, or participation certificates for completing this activity.

Learning Objectives:
1. Demonstrate the clinical management decisions for a patient with a grade II oligodendroglioma that initially presented with seizures.
2. Convey the importance of using IDH testing in the diagnosis and clinical management of patients with diffuse gliomas.
3. Explain the classification of oligodendroglioma, which now incorporates IDH mutation and 1/19q co-deletion into the definition.

Competencies Addressed:
Medical Knowledge (ACGME, AAPA)
Health Promotion, Health Protection, Disease Prevention, and Treatment (ONS)