Carcinoma of Unknown Primary (August 2015): Molecular Oncology Tumor Boards

This free case-based activity includes a crowd-sourced discussion of 26 year old woman (never smoker) had RLQ abdominal pain which was persistent and severe. CT scans of the chest, abdomen/pelvis showed an ovarian mass and PET scan revealed increased uptake in the mass as well as in normal-sized right supraclavicular and mediastinal nodes and the right sixth rib.  

Originally posted on a forum in the ASCO Connection, users now have the opportunity to claim CME, completion, or participation certificates for completing this activity. 

Learning Objectives:

  • Evaluate what tumor types should be considered with a differential diagnosis of CK7+ CK20+ and discussion of selected  other IHC stains in determining the cancer type in CUP 
  • Determine the potential clinical importance of an ALK rearrangement (fusion gene)  in CUP
  • Analyze the role of genetic testing in identifying the site of origin and guiding therapy for CUP patients

This activity was made available on 8/26/2015 and will be reviewed on an annual basis to determine continued availability. A maximum of 1 AMA PRA Category 1 Credit(s) ™ credit is available.

Competencies Addressed

Medical Knowledge (ACGME, AAPA)

Health Promotion, Health Protection, Disease Prevention, and Treatment (ONS)