Acute Myeloid Leukemia: Molecular Oncology Tumor Boards

This free case-based activity includes a crowd-sourced discussion of a 59-year-old male who presented with gum swelling and bleeding, an abnormal CBC, and physical examination was remarkable for gingival hyperplasia as well as 1-2 cm bilateral cervical and submandibular adenopathy. Review of the peripheral smear demonstrated frequent blasts and promonocytes. Immature monocytes and neutrophils with hypersegmented nuclei and occasionally with hypogranular cytoplasm were present. There was a macrocytic anemia with anisocytosis and a moderate thrombocytopenia with hypogranular forms seen.

Originally posted on a forum in the ASCO Connection, users now have the opportunity to claim CME, completion, or participation certificates for completing this activity.

Learning Objectives:
1. Recognize the clinical characteristics and outcomes for patients with FLT3 mutations?
2. Describe the role of FLT3 inhibitors for the initial treatment of AML?
3. Understand the role of gene mutations, including CLT3, in the pathologic classification of AML

Competencies Addressed
Medical Knowledge (ACGME, AAPA)
Health Promotion, Health Protection, Disease Prevention, and Treatment (ONS)

Target Audience
This course is designed for members of the cancer care team including medical, radiation and surgical oncologists, pathologists, and oncology fellows.