Acute Myeloid Leukemia (MLL Rearrangement): Molecular Oncology Tumor Boards

This free case-based activity includes a crowd-sourced discussion of 67 Year old female presented with painful nodular skin lesions mainly involving the face and the extremities of 6 weeks duration. FISH studies identified the MLLT4-MLL rearrangement in 94% of analyzed nuclei.  Molecular studies for FLT3, NPM1 and CEBPA were negative.

Originally posted on a forum in the ASCO Connection, users now have the opportunity to claim a CME, completion, or participation certificate for completing this activity. 

Learning Objectives:

  • Determine the differential diagnosis of skin rashes that precede or accompany a diagnosis of acute myeloid leukemia (AML)
  • Evaluate the prognostic significance of the MLL gene rearrangement in AML
  • Analyze the role of molecular testing (next generation sequencing and RNA sequencing) in prognostication and therapeutics of patients with AML

Competencies Addressed

Medical Knowledge (ACGME, AAPA)

Health Promotion, Health Protection, Disease Prevention, and Treatment (ONS)